Beryllium (PVD coated on Ti, 10μm, Cu, 10μm), different thickness of oxygen-free cooper (OFC) sheets as transitionlayer and CuCrZr/316L(N) explosive bi-metallic plates are bonded by hot isostatic pressing (HIP), optical microscope, scanning electron microscope(SEM), Electron Probe Micro-analyzer(EPMA), X-ray diffraction( XRD), shearing tests are used to verify the diffusion bonding performance. Results turn out to be all kinds of mock-ups successfully bonded, no any cracks have been found in the diffusion bonding interface, three different kinds of diffusion layers are found between titanium and copper which are CuTi2、CuTi and Cu4Ti, respectively. The thicker of the OFC layer is, the better the shearing testing performance is.