The physics analysis of hybrid operation scenario for the new medium-sized tokamak HL-2M under construction is simulated, based on OMFIT integrated modeling framework. Under the condition of plasma current of 1MA and toroidal magnetic field of 1.88T, a hybrid operation scenario is achieved with a flat core q profile around 1 by implementing the auxiliary heating and current drive of electron cyclotron wave (ECW) and neutral beam injection (NBI). In this case, the fractions of ohmic current and bootstrap current are 26% and 42% respectively, and the energy confinement factor H98,y2 is as high as 1.19. In order to obtain a higher normalized beta βN under the condition of hybrid operation, a counter injection of NBI must be added. Moreover, optimizing off-axis ECCD and increasing on-axis NBI power can contribute to fully non-inductive hybrid operation, in which the βN is 3.47, H98,y2 is 1.14 and bootstrap current fraction is 51%.