In order to ensure the stable operation of EAST fast control power supply, a new AC insulation monitoring technique, suitable for the high-frequency and high-voltage working environment of EAST fast control power supply, was presented. The unbalanced bridge of resistance was applied to cause changes in the partial voltage of the resistances by alternately switching, then voltages were collected real-time, and the value of insulation resistance could be calculated. The simulation platform based on Simulink was built to carry out real-time insulation monitoring analysis with ~220V and output of EAST fast control power supply as voltage input, and the waveforms were consistent with the expected. Through experimental verification, the new method can accurately complete the insulation monitoring of 220V AC input, and can work well in the fast control power supply field, where the accuracy of insulation monitoring is achieved.